By J. Skoda, Peter Langen
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Ever due to the fact that we all started huddling jointly in caves, the tale of human background has been inextricably wed to the tale of microbes. micro organism and viruses have advanced and unfold between us, shaping our society while our altering human tradition has formed their evolutionary path.
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Extra resources for Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978
Ep. Ep. 7 x 1 0 " 7 χ 10- Inhibitor Hydroxyurea IQ-1 qn 4 5 6 8 8 7 (11) (16) (11) * Concentration required for 50% inhibition. Investigation of the kinetic mechanism of inhibition of ribonucleotide reductase by the heteroaromatic thiosemicarbazones is complicated by the impure nature of the ribonucleotide reductase preparations employed. Nevertheless, the findings indicate that CDP, the nucleoside diphosphate substrate; ATP, the allosteric activator; and magnesium ion are noncompetitive with respect to IQ-1 and 2formylpyridine thiosemicarbazone (PT).
19) W. P. Jencks (1969) Catalysis in Chemistry and Enzymology, McGraw-Hill, New York, pp. 323-350. (20) J . H. Galivan, G. F. Maley and F. Maley, Biochemistry 15, 356 (1976). (21) C. Heidelberger, D. G. Parsons and D. C. Remy, J . Med. Chem. 7, 1 (1964). (22) Τ. T. Sakai and D. V. Santi, J . Med. Chem. 16, 1079 (1973). (23) D. V. Santi and Τ. T. Sakai, Biochemistry 10, 3598 (1971). (24) I. H. Pitman, M. J . Cho and G. S. Rork, J . Am. Chem. Soc. 96, 1840 (1974). " (25) R. B. Dunlap, N. G. L. Harding and F.
Biochem. Biophys. 184, 346 (1977). L. Pogolotti, Κ. M. Ivanetich, H. Sommer, and D. V. Santi, Thymidylate synthetase: Studies on the peptide containing covalent bound 5-fluoro-2'-deoxyuridylate and methylenetetrahydrofolate, Biochem. Biophys. Res. Commun. 70, 972 (1976). L. Bellisario, G. F. Maley, D. U. Guarino, and F. Maley, The complete amino acid sequence of Lactobacillus casei thymidylate synthetase, Fed. Proc. 37, 1617 (1978). f 1 34. Y, 35. C, 36. C. 37. J, 38. J. 39. J. 40. A. 41. R. 31 PHARMACOLOGY OF 5-AZA-2'-DEOXYCYTIDINE Richard L.